I-Ren Lee
Name I-Ren Lee
Email
Office Tel No. 02-77496115
Title Associate Professor
  1. I-R. Lee, T. Akinyi, A. G. Kozlov, T. M. Lohman, T. Ha, “Single Molecule Observation of Direct Transfer of Escherichia Coli Single-Strand Binding Protein (SSB) between Single-Stranded DNA Molecules” In Preparation. 
  2. I-R. Lee; A. Gahlmann; A. H. Zewail “Structural Dynamics of Free Amino Acids in Diffraction” Angewandte Chemie International Edition, 2012, 51, 99-102. 
  3. A. Gahlmann; I-R. Lee; A.H. Zewail “Direct Structural Determination of Conformations of Photoswitchable Molecules by Laser Desorption-Electron Diffraction” Angewandte Chemie International Edition 2010, 49, 6524-6527.
  4. I-R. Lee; W. Lee; A. H. Zewail “Dynamics of Electrons in Ammonia Cages: The Discovery System of Solvation” Chemphyschem 2008, 9, 83-88. 
  5. I-R. Lee; L. Baares; A. H. Zewail “Direct Observation of the Primary Bond-twisting Dynamics of Stilbene Anion Radical” Journal of the American. Chemical. Society 2008, 130, 6708-6709. 
  6. H. Y. Chen; I-R. Lee; P. Y. Cheng ”Gas-phase Femtosecond Transient Absorption Spectroscopy” Review of Scientific. Instruments 2006, 77, 076105.  
  7. I-R. Lee; W. Lee; A. H. Zewail “The Primary Step of the Photoactive Yellow Protein: Isolated Chromophore Dynamics and Protein Directed Function” Proceedings of the National Academy of Sciences of the United States of America 2006, 103, 258-262. 
  8. D. H. Paik; I-R. Lee; D. S. Yang; J. S. Baskin; A. H. Zewail “Electrons in Finite-sized Water Cavities: Hydration Dynamics Observed in Real Time” Science 2004, 306, 672-675. 
  9. D. H. Paik; D. S. Yang; I-R. Lee; A. H. Zewail “The Transition State of Thermal Organic Reactions: Direct Observation in Real Time” Angewandte Chemie International Edition 2004, 43, 2830-2834. 
  10. I-R. Lee; Y. C. Chung; W. K. Chen; X. P. Hong; P. Y. Cheng “Femtosecond Probing of Photodissociation Dynamics in Acyl Cyanides” Journal of Chemical Physics 2001, 115, 10656-10670.
  11. I-R. Lee; W. K. Chen; Y. C. Chung; P. Y. Cheng “A Direct Observation of Non-RRKM Behavior in Femtosecond Photophysically Activated Reactions” Journal of Physical Chemistry 2000, 104, 10595-10599.
  12. C. G. Lu; R. M. R. Hsieh; I-R. Lee; P. Y. Cheng “Ultrafast Dynamics of Gas-phase Excited-state Intramolecular Proton Transfer in 1-Hydroxy-2-Acetonaphthone” Chemical Physics Letter 1999, 310,103-110. 
Year Paper Title
2019 Mononuclear Manganese(III) Superoxo Complexes: Synthesis, Characterization, and Reactivity, Inorganic Chemistry, vol. 58, Jul. 2019
2019 Long-Range Hairpin Slippage Reconfiguration Dynamics in Trinucleotide Repeat Sequences, Journal of Physical Chemistry Letters, vol. 10, Jun. 2019
2018 Determination of Gold Ions in Human Urine Using Genetically Engineered Microorganisms on a Paper Device, ACS Sensors, vol. 3, Mar. 2018
2017 Parity-dependent hairpin configurations of repetitive DNA sequence promote slippage associated with DNA expansion, Proceedings of the National Academy of Sciences of the United States of America, vol. 114, Jul. 2017
 I-R. Lee, T. Akinyi, T. Ha, “Single Molecule Observation of Direct Transfer of Escherichia Coli Single-Strand Binding Protein (SSB) between Single-Stranded DNA Molecules” Biophysical Society 57th Annual Meeting, February, 2013, Philadelphia, PA, USA. 
Year Paper Title
2019 Long-Range Slippery Hairpin Reconfiguration and its Mechanism in Trinucleotide Repeats Revealed by Single-Molecule Spectroscopy, Annual Meeting of the Biophysical Society, Mar. 02-06, 2019, Baltimore, USA
2015 The effect of magnesium cations on the folding of Gquadruplex, The 9th International Conference on Advanced Materials and Devices, Dec. 07-09, 2015, Jeju, Korea
2014 Single-molecule study on the formation and dynamics of G-quadruplex in the presence of magnesium cations, 19th East Asian Workshop on Chemical Dynamics, Oct. 04-07, 2014, Gold Coast, Australia
Year Project Title Job Title Period Unit
2018 單分子結構動態學研究-導致基因疾病的連續核酸序列 主持人 2016.04 ~ 2018.07 科技部(原國科會)
2017 以單分子光譜研究去氧核醣核酸分子之結構動態學 主持人 2014.08 ~ 2017.07 科技部(原國科會)
Country School Name Department Degree Duration
U.S. Caltech Chemistry Ph.D. 2003.06 ~ 2010.12
Taiwan National Tsing Hua University chemistry M.S. 2000.09 ~ 2002.06
Taiwan National Tsing Hua University Chemistry B.S. 1995.09 ~ 1998.06
Taiwan National Chiao Tung University The Department of Applied Chemistry 1994.09 ~ 1995.06
Organization Title Department Job Title Duration
UIUC Department of physical Postdoctoral Fellow 2012.02 ~ 2014.01
Caltech Department of chemistry Postdoctoral Fellow 2011.01 ~ 2012.01