杜玲娴
姓名 杜玲娴
电子邮件
联络电话 02-7749-6157
实验室电话 02-7749-6178
职称 教授
研究领域 有机化学,生物化学, 蛋白质错误折叠与疾病研究
指导学生 硕二: 黄景鸿、李亭慧、单珮雅
硕一:  黄慈瑄、张家绮、潘沛君
1. Ling-Hsien Tu, Ning-Hsuan Tseng, Ya-Ru Tsai, Tien-Wei Lin, Yi-Wei Lo, Jien-Lin Charng, Hua-Ting Hsu, Yu-Sheng Chen, Rong-Jie Chen, Ying-Ta Wu, Yi-Tsu Chan, Chang-Shi Chen, Jim-Min Fang,* and Yun-Ru Chen* (2018, Oct). Rationally designed divalent caffeic amides inhibit amyloid-β fibrillization, induce fibril dissociation, and ameliorate cytotoxicity. European Journal of Medicinal Chemistry, 158, 393-404 
2. Arnaldo Serrano, Justin Lomont, Ling-Hsien Tu, Daniel Raleigh, and Martin Zanni* (2017, Oct). A free energy barrier caused by the refolding of an oligomeric intermediate controls the lag time of amyloid formation by hIAPP. Journal of the American Chemical Society, 139(46), pp 16748–16758. 
3. Lydia M. Young, Ling-Hsien Tu, Daniel P. Raleigh, Alison E. Ashcroft, and Sheena E. Radford* (2017, May). Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers. Chemical Science, 8(7), 5030-5040.
4. Andisheh Abedini*, Annette Plesner, Ping Cao, Zachary Ridgway, Jinghua Zhang, Ling-Hsien Tu, Chris T Middleton, Brian Chao, Daniel J Sartori, Fanling Meng, Hui Wang, Amy G Wong, Martin T Zanni,C Bruce Verchere, Daniel P Raleigh*, Ann Marie Schmidt* (2016, May). Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics. eLIFE, 5:e12977. 
5. Rehana Akter, Ping Cao, Harris Noor, Zachary Ridgway, Ling-Hsien Tu, HuiWang, Amy G.Wong, Xiaoxue Zhang, Andisheh Abedini, AnnMarie Schmidt, and Daniel P. Raleigh* (2016). Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology. Journal of Diabetes Research, Article ID 2798269. 
6. Daniel T. Meier, Ling-Hsien Tu, Sakeneh Zraika, Meghan F. Hogan, Andrew T. Templin, Rebecca L. Hull, Daniel P. Raleigh, and Steven E. Kahn* (2015, Dec). Matrix Metalloproteinase-9 Protects Islets from Amyloid induced Toxicity. Journal of Biological Chemistry, 290(51), 30475–30485. co-first author
7. Lydia M. Young, Rachel A. Mahood, Janet C. Saunders, Ling-Hsien Tu, Daniel P. Raleigh, Sheena E. Radford* and Alison E. Ashcroft* (2015, Oct). Insights into the consequences of co-polymerisation in the early stages of IAPP and Aβ peptide assembly from mass spectrometry. Analyst, 140, 6990–6999. 
8. Ling-Hsien Tu, Lydia M. Young, Amy G. Wong, Alison E. Ashcroft, Sheena E. Radford, and Daniel P. Raleigh* (2015, Jan). Mutational Analysis of the Ability of Resveratrol To Inhibit Amyloid Formation by Islet Amyloid Polypeptide: Critical Evaluation of the Importance of Aromatic−Inhibitor and Histidine−Inhibitor Interactions. Biochemistry, 54, 666-676. 
9. Lydia M. Young, Janet C. Saunders, Rachel A. Mahood, Charlotte H. Revill1, Richard J. Foster, Ling-Hsien Tu, Daniel P. Raleigh, Sheena E. Radford* and Alison E. Ashcroft* (2015, Jan). Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry–mass spectrometry. Nature Chemistry, 7, 73-81. 
10. Ling-Hsien Tu, Harris Noor, Ping Cao, and Daniel P. Raleigh* (2014, May). Aspirin, Diabetes, and Amyloid: Re-examination of the Inhibition of Amyloid Formation by Aspirin and Ketoprofen. ACS Chemical Biology, 9, 1632-1637.
11. Ling-Hsien Tu, Arnaldo L. Serrano, Martin T. Zanni, and Daniel P. Raleigh* (2014, Apr). Mutational Analysis of Preamyloid Intermediates: The Role of His-Tyr Interactions in Islet Amyloid Formation. Biophysical Journal, 106, 1520-1527.  
12. Ping Cao, Andisheh Abedini, Hui Wang, Ling-Hsien Tu, Xiaoxue Zhang, Ann Marie Schmidt, and Daniel P. Raleigh* (2013, Nov). Islet amyloid polypeptide toxicity and membrane interactions. Proceedings of the National Academy of Sciences, 110(48), 19279–19284. 
13. Ping Cao, Peter Marek, Harris Noor, Vadim Patsalo, Ling-Hsien Tu, Hui Wang, Andisheh Abedini, Daniel P. Raleigh* (2013, Apr). Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity. FEBS Letter, 587, 1106–1118. 
14. Ling-Hsien Tu and Daniel P. Raleigh* (2013, Jan). Role of Aromatic Interactions in Amyloid Formation by Islet Amyloid Polypeptide. Biochemistry, 52, 333-342. 
15. Ping Cao, Ling-Hsien Tu, Andisheh Abedini, Olesya Levsh, Rehana Akter, Vadim Patsalo, Ann Marie Schmidt, and Daniel P. Raleigh* (2012, Aug). Sensitivity of Amyloid Formation by Human Islet Amyloid Polypeptide to Mutations at Residue 20. Journal of Molecular Biology, 421, 282–295. 
16. Ming-Chang P. Yeh,* Wei-Jou Yeh, Ling-Hsien Tu, and Jia-Ru Wu (2006, Jun). CeCl3.7H2O–NaI catalyzed intramolecular addition reactions of 7-hydroxy-1,3-dienes: a facile approach to hexahydrobenzofurans and tetrahydrofurans. Tetrahedron, 62, 7466–7470. 
17. Ming-Chang P. Yeh,* Wen-Cheng Tsao, and Ling-Hsien Tu (2005, Oct). Palladium-Catalyzed Reaction of Aryl Bromides with 7-Hydroxy-1,3-Dienes. Organometallics, 24, 5909-5915. 
18.  Ming-Chang P. Yeh,* Wen-Cheng Tsao, Jin-Shen Ho, Chih-Chuan Tai, Dai-Yu Chiou, and Ling-Hsien Tu (2004, Jan). Rhodium(I)-Catalyzed Intramolecular Cyclohexadienyl Pauson-Khand Reaction: Facile Approach to Tricarbocycles. Organometallics, 23, 792-799. 
年度 论文名称
2024 Unraveling the Underlying Mechanisms of Reduced Amyloidogenic Properties in Human Calcitonin via Double Mutations, Protein Science, Apr. 2024
2024 TPE conjugated islet amyloid polypeptide probe for detection of peptide oligomers, Biophysical Chemistry, Jan. 2024
2023 Beta amyloid oligomers with higher cytotoxicity have higher sidechain dynamics, Chemistry – A European Journal, Oct. 2023
2023 Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity, Chemical Communications, vol. 59, Aug. 2023
2023 Synthesis of Fe3O4-Chlorophyllin Nanoparticles for Preventing Amyloid Formation by Human Calcitonin, ACS Applied Nano Materials, vol. 6, Jul. 2023
2023 Investigating the inhibitory property of DM hCT on hCT fibrillization via its relevant peptide fragments, Protein Science, vol. 32, Jun. 2023
2023 An environmentally sensitive molecular rotor as a NIR fluorescent probe for the detection of islet amyloid polypeptide, Talanta, vol. 254, Mar. 2023
2022 Aβ42 oligomers can seed the fibrillization of Aβ40 peptides, Journal of the Chinese Chemical Society, Aug. 2022
2022 Dihydrocaffeic acid decorated iron oxide nanomaterials effectively inhibit human calcitonin aggregation, ACS Omega, vol. 7, Aug. 2022
2022 Site specific NMR characterization of abeta-40 oligomers cross seeded by abeta-42 oligomers, Chemical Science, vol. 13, Jun. 2022
2022 Tyrosine 12 of human calcitonin modulates its amyloid formation, membrane binding, and bioactivity, Biochimie, vol. 197, Jun. 2022
2022 The Role of Aldehyde-Functionalized Crosslinkers on the Property of Chitosan Hydrogels, Macromolecular Bioscience, Feb. 2022
2021 Dopamine-Conjugated Carbon Dots Inhibit Human Calcitonin Fibrillation, nanomaterials, vol. 11, Aug. 2021
2021 Exploring the impact of glyoxal glycation on β-amyloid peptide (Aβ) aggregation in Alzheimer's disease, J. Phys. Chem. B, May. 2021
2020 TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease, Nature Communications, vol. 11, Dec. 2020
2020 Role of Lysine Residue of Islet Amyloid Polypeptide in Fibril Formation, Membrane Binding, and Inhibitor Binding, Biochimie, vol. 177, Aug. 2020
2020 A Fluorogenic Molecule for Probing Islet Amyloid Using Flavonoid as a Scaffold Design, Biochemistry, vol. 59, Apr. 2020
2019 Inhibiting Human Calcitonin Fibril Formation with Its Most Relevant Aggregation-Resistant Analog, J. Phys. Chem. B, vol. 123, Nov. 2019
2019 Protein Glycation by Glyoxal Promotes Amyloid Formation by Islet Amyloid Polypeptide, Biophysical Journal, vol. 116, Jun. 2019
2018 Rationally designed divalent caffeic amides inhibit amyloid-β fibrillization, induce fibril dissociation, and ameliorate cytotoxicity, European Journal of Medicinal Chemistry, vol. 158, Oct. 2018
2017 A Free Energy Barrier Caused by the Refolding of an Oligomeric Intermediate Controls the Lag Time of Amyloid Formation by hIAPP, Journal of the American Chemical Society, vol. 139, Nov. 2017
2017 Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers, Chemical Science, vol. 8, May. 2017
2016 Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics, eLIFE, vol. N/A, May. 2016
2016 Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology, Journal of Diabetes Research, vol. 2016, Jan. 2016
2015 Matrix metalloproteinase-9 protects islets from amyloidinduced toxicity, Journal of Biological Chemistry, vol. 290, Dec. 2015
2015 Insights into the consequences of co-polymerisation in the early stages of IAPP and Aβ peptide assembly from mass spectrometry, Analyst, vol. 140, Oct. 2015
2015 Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry–mass spectrometry, Nature Chemistry, vol. 7, Jan. 2015
2015 Mutational Analysis of the Ability of Resveratrol To Inhibit Amyloid Formation by Islet Amyloid Polypeptide: Critical Evaluation of the Importance of Aromatic−Inhibitor and Histidine−Inhibitor Interactions, Biochemistry, vol. 54, Jan. 2015
2014 Aspirin, Diabetes, and Amyloid: Re-examination of the Inhibition of Amyloid Formation by Aspirin and Ketoprofen, ACS Chemical Biology, vol. 9, May. 2014
2014 Mutational Analysis of Preamyloid Intermediates: The Role of His-Tyr Interactions in Islet Amyloid Formation, Biophysical Journal, vol. 106, Apr. 2014
2013 Islet amyloid polypeptide toxicity and membrane interactions, Proceedings of the National Academy of Sciences of the United States of America, vol. 110, Nov. 2013
2013 Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity, FEBS Letters, vol. 578, Apr. 2013
2013 Role of Aromatic Interactions in Amyloid Formation by Islet Amyloid Polypeptide, Biochemistry, vol. 52, Jan. 2013
2012 Sensitivity of Amyloid Formation by Human Islet Amyloid Polypeptide to Mutations at Residue 20, Journal of Molecular Biology, vol. 421, Aug. 2012
2006 CeCl3·7H2O-NaI catalyzed intramolecular addition reactions of 7-hydroxy-1,3-dienes: a facile approach to hexahydrobenzofurans and tetrahydrofurans, Tetrahedron, vol. 62, Jun. 2006
2005 Palladium-Catalyzed Reaction of Aryl Bromides with 7-Hydroxy-1,3-Dienes, Organometallics, vol. 24, Oct. 2005
2004 Rhodium(I)-Catalyzed Intramolecular Cyclohexadienyl Pauson-Khand Reaction: Facile Approach to Tricarbocycles, Organometallics, vol. 23, Jan. 2004
年度 论文名称
2019 Minimum Acquisition of Double Mutation in Human Calcitonin Enhances its Resistance to Fibrillization and its Use as Therapeutic Polypeptides, 26th American peptide symposium, Jun. 22-27, 2019, Monterey, USA
年度 计画名称 参与人 职称/担任之工作 计画期间 补助/委讬或合作机构
2022 以第二型糖尿病中有毒蛋白质寡聚体为目标，发展其侦测方式及策略计画以调控其生成(2/3) 2021.08 ~ 2022.07 国科会
2021 以第二型糖尿病中有毒蛋白质寡聚体为目标，发展其侦测方式及策略计 画以调控其生成(1/3) 主持人 2020.08 ~ 2021.07 科技部(原国科会)
2019 光敏性抗菌奈米纤维不织布于伤口敷料上之应用 国立台湾师范大学 协同/共同主持人 2019.03 ~ 2019.12 其他
2020 探讨与氧化压力相关的异常键结修饰对阿兹海默病症β-类淀粉蛋白质聚集的影响 主持人 2018.08 ~ 2020.07 科技部(原国科会)
2018 研究醣化过程造成类淀粉蛋白产生的机制 主持人 2016.12 ~ 2018.07 科技部(原国科会)
国家 学校名称 系所 学位 期间
美国 纽约州立大学石溪分校 化学所 博士 2008.08 ~ 2014.08
台湾 国立台湾师范大学 化学系 硕士 2003.09 ~ 2005.07
台湾 国立台湾师范大学 化学系 学士 1999.09 ~ 2003.06
服务机关名称 单位 职务 期间
副教授 2021.02 ~ 迄今
国立台湾师范大学 化学系 助理教授 2016.08 ~ 2021.01
中央研究院 基因体中心 博士后研究学者 2014.09 ~ 2016.07