张焕正
姓名 张焕正
电子邮件
联络电话 +886-2-2366-8260
网站 https://www.iams.sinica.edu.tw/tw/?link=member&id=24
实验室电话 +886-2-2366-8226, +886-2-2366-8249
职称 教授
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研究领域 生物物理化学、生物质谱学，着重于新型质谱技术的开发与应用、奈米光子学，着重于高亮度萤光奈米钻石的开发及其在生物成像方面的应用、奈米生物技术，着重于开发奈米钻石成为生物分子萃取、浓缩、检测、与结晶的基质
 
  1. W. W.-W. Hsiao, Y. Y. Hui, P.-C. Tsai, and H.-C. Chang*, “Fluorescent nanodiamond: A versatile tool for long-term cell tracking, super-resolution imaging, and nanoscale temperature sensing,” Acc. Chem. Res. 49, 400–407 (2016).
  2. Y.-K. Tzeng, P.-C. Tsai, H.-Y. Liu, O. Y. Chen, H. Hsu, F.-G. Yee, M.-S. Chang*, and H.-C. Chang*, “Time-resolved luminescence nanothermometry with nitrogen-vacancy centers in nanodiamonds,” Nano Lett. 15, 3945–3952 (2015).
  3. T.-J. Wu, Y.-K. Tzeng, W.-W. Chang, C.-A. Cheng, Y. Kuo, C.-H. Chien, H.-C. Chang*, and J. Yu*, “Tracking the engraftment and regenerative capabilities of transplanted lung stem cells using fluorescent nanodiamonds,” Nature Nanotech.8, 682–689 (2013).
  4. V. Vaijayanthimala, P.-Y. Cheng, S.-H. Yeh, K.-K. Liu, C.-H. Hsiao*, J.-I. Chao*, and H.-C. Chang*, “The long-term stability and biocompatibility of fluorescent nanodiamond as an in vivo contrast agent,” Biomaterials 33, 7794–7802 (2012). 
  5. Y.-K. Tzeng, O. Faklaris, B.-M. Chang, Y. Kuo, J.-H. Hsu, and H.-C. Chang*, “Superresolution imaging of albumin-conjugated fluorescent nanodiamonds in cells by stimulated emission depletion,” Angew. Chem. Int. Ed. 50, 2262–2265 (2011).
  6. N. Mohan, C.-S. Chen, H.-H. Hsieh, Y.-C. Wu*, and H.-C. Chang*, “In vivo imaging and toxicity assessments of fluorescent nanodiamonds in Caenorhabditis elegans,” Nano Lett. 10, 3692–3699 (2010).
  7. H.-C. Chang*, “Ultrahigh-mass mass spectrometry of single biomolecules and bioparticles,” Annu. Rev. Anal. Chem. 2, 169–185 (2009).
  8. Y.-R. Chang, H.-Y. Lee, K. Chen, C.-C. Chang, D.-S. Tsai, C.-C. Fu, T.-S. Lim, Y.-K. Tzeng, C.-Y. Fang, C.-C. Han, H.-C. Chang*, and W. Fann*, “Mass production and dynamic imaging of fluorescent nanodiamonds,” Nature Nanotech. 3, 284–288 (2008).
  9. C.-C. Fu, H.-Y. Lee, K. Chen, T.-S. Lim, H.-Y. Wu, P.-K. Lin, P.-K. Wei, P.-H. Tsao, H.-C. Chang*, and W. Fann*, “Characterization and application of single fluorescent nanodiamonds as cellular biomarkers,” Proc. Natl. Acad. Sci. USA104, 727–732 (2007).
  10. Z. X. Nie, Y.-K. Tzeng, H.-C. Chang*, C.-C. Chiu, C.-Y. Chang, C.-M. Chang, and M.-H. Tao, “Microscopy-based mass measurement of a single whole virus in a cylindrical ion trap,” Angew. Chem. Int. Ed. 45, 8131–8134 (2006).
  11. S.-J. Yu, M.-W. Kang, H.-C. Chang*, K.-M. Chen, and Y.-C. Yu, “Bright fluorescent nanodiamonds: No photobleaching and low cytotoxicity,” J. Am. Chem. Soc. 127, 17604–17605 (2005).
  12. X. L. Kong, L. C. L. Huang, C.-M. Hsu, W.-H. Chen, C.-C. Han, and H.-C. Chang*, “High-affinity capture of proteins by diamond nanoparticles for mass spectrometric analysis,” Anal. Chem. 77, 259–265 (2005).
  13. H.-C. Chang*, C.-C. Wu, and J.-L. Kuo*, “Recent advances in understanding the structures of medium-sized protonated water clusters,” Int. Rev. Phys. Chem. 24, 553–578 (2005).
  14. L. C. L. Huang and H.-C. Chang*, “Adsorption and immobilization of cytochrome c on nanodiamonds,” Langmuir 20, 5879–5884 (2004).
  15. J. C. Jiang, H.-C. Chang, Y.-S. Wang, S. H. Lin, Y. T. Lee, G. Niedner-Schatteburg, and H.-C. Chang*, “Infrared spectra of H+(H2O)5-8 clusters: Evidence for symmetric proton hydration,” J. Am. Chem. Soc. 122, 1398–1410 (2000).
  16. C.-L. Cheng, H.-C. Chang*, J.-C. Lin*, K.-J. Song, and J.-K. Wang, “Direct observation of hydrogen etching anisotropy on diamond single crystal surfaces,” Phys. Rev. Lett. 78, 3712−3716 (1997).