吴学亮
姓名 吴学亮
电子邮件 hlw@ntnu.edu.tw
联络电话 (02)77496142
实验室电话 (02)77496155
职称 优聘教授
研究领域 有机化学 不对称合成 天然物合成 药物合成
学术专长 有机合成化学 有机金属化学
指导学生 博士后：李韦贤。
博士班： 曾昊葳，程友毅， 杨玉珠
硕士班：萧萱霈，林羽宣，邱奕文，张景智，陈承威，郭瑀洁，蔡宇轩，黄俊杰 
实验室 不对称合成实验室

学术着作

  1. Wei-Sian Li, Ting-Shen Kuo, Meng-Chi Hsieh, Ming-Kang Tsai, Ping-Yu Yu, Hsyueh-Liang Wu* "Enantioselective Rhodium-Catalyzed Allylation of Aliphatic Imines: Synthesis of Chiral C-Aliphatic Homoallylic Amines" Org. Lett. 2020, 22, 5675-5679.
  2. Hao-Wei Zeng, Ping-Yu Wu, Hsyueh-Liang Wu* "Progress in recent development of stereoselective synthesis of beta2-amino acid derivatives from beta-nitroacrylate derivatives" Org. Biomol. Chem. 2020, 18, 2991-3006.
  3. Jia-Hong Jian, Hao-Wei Zeng, Ting-Shen Kuo, Ping-Yu Wu, Hsyueh-Liang Wu* "Asymmetric Synthesis of Functionalized Phenylalanine Derivatives via Rh-Catalyzed Conjugate Addition and Enantioselective Protonation Cascade" Org. Lett. 2019, 21, 9468-9472.
  4. Jin-Fong Syu, Balraj, Gopula, Jia-Hong Jian, Wei-Sian Li, Ting-Shen Kuo, Ping-Yu Wu, Julian P. Henschke, Meng-Chi Hsieh, Ming-Kang Tsai, Hsyueh-Liang Wu* "Asymmetric Synthesis of beta-Aryl beta-Imido Sulfones Using Rhodium Catalysts with Chiral Diene Ligands: Synthesis of Apremilast" Org. Lett. 2019, 21, 4614-4618.
  5. Jia-Hong Jian, Chih-Lung Hsu, Jin-Fong Syu, Ting-Shen Kuo, Ming-Kang Tsai, Ping-Yu Wu, Hsyuh-Liang Wu* "Access to ß2-Amino Acids via Enantioselective 1,4-Arylation of ß-Nitroacrylates Catalyzed by Chiral Rhodium Catalysts" J. Org. Chem. 2018, 83, 12184–12191.
  6. Chiung-An Chang, Tsung-Ying Uang, Jia-Hong Jian, Meng-Yi Zhou, Ming-Liang Chen, Ting-Shen Kuo, Ping-Yu Wu, and Hsyueh-Liang Wu* "Efficient and Enantioselective Rhodium(I)-Catalyzed Arylation of alpha-Ketoesters: Synthesis of (S)-Flutriafol"  Adv. Syn. Cat. 2018, 360, 3381-3390.
    参考连结参考连结
  7. Chiang, Pei-Feng; Li, Wei-Sian; Jian, Jia-Hong ; Kuo, Ting-Shen; Wu, Ping-Yu; Wu, Hsyueh-Liang  "Rh-catalyzed Enantioselective Allylation of N-Ts and N-Ns Aldimines: Total Synthesis of (–)-Crispine A" Org. Lett. 2018, 20, 158–161.
    参考连结参考连结
  8. Jin-Fong Syu, Huang-Ying Lin, Yu-Yi Cheng, Yao-Chu Tsai, Yi-Ching Ting, Ting-Shen Kuo, Damodar Janmanchi, Ping-Yu Wu, Julian P. Henschke and Hsyueh-Liang Wu* "Design and Synthesis of Chiral Diene Ligands for Rh(I)-Catalyzed Enantioselective Arylation of N-DPP-protected Aldimines: Synthesis of the Antifungal Agent Bifonazole" Chem. Eur. J. 2017, 23, 14515–14522.
    参考连结参考连结
  9. Hsyueh-Liang Wu,* Chiung-An Chang, Ping-Yu Wu, Biing-Jiun Uang.* "Recent developents in Zn-catalyzed asymmetric addition reaction to ketones: Syntheses of chiral tertiary alcohols" Tetrahedron Lett 2017, 58, 706–710.  参考连结参考连结
  10. Jin-Fong Syu, Yun-Ting Wang, Kung-Cheng Liu, Ping-Yu Wu, Julian P. Henschke,*, and Hsyueh-Liang Wu*, "Rh(I)-Catalyzed 1,4-Conjugate Addition of Alkenylboronic Acids to a Cyclopentenone Useful for the Synthesis of Prostaglandins" J. Org. Chem. 2016, 81, 10832–10844. 参考连结参考连结
  11. Jo-Hsuan Fang, Jia-Hong Jian, Hao-Ching Chang,Ting-Shen Kuo, Way-Zen Lee, Hsyueh-Liang Wu.* "Synthesis of Quaternary Carbon-containing β2,2-Amino Acids via Rh(I)-Catalyzed Enantioselective Arylation of α-Substituted β-Nitroacrylates" Chem. Eur.–J. 2017, 23, 1830–1838. 参考连结参考连结
  12.  Hsyueh-Liang Wu, Ping-Yu Wu, Ying-Ni Cheng, Biing-Jiun Uang,* "Enantioselective addition of organozinc reagents to carbonyl compounds catalyzed by a camphor derived chiral gamma-amino thiol ligand" Tetrahedron 2016, 72, 2656–2665 参考连结参考连结
  13. Jo-Hsuan Fang, Chiung-An Chang, Balraj Gopula,Ting-Shen Kuo, Ping-Yu Wu, Julian P. Henschke, and Hsyueh-Liang Wu* "Rhodium-Catalyzed Enantioselective Arylation of N-Substituted alpha,beta-Unsaturated gamma-Lactams: Preparation of Chiral 4-Aryl-2- Pyrrolidones" Asian J. Org. Chem. 2016, 5, 481 – 485  参考连结参考连结
  14. Balraj Gopula, Shu-Han Yang, Ting-Shen Kuo, Jen-Chieh Hsieh,* Ping-Yu Wu, Julian P. Henschke,* and Hsyueh-Liang Wu* "Direct Synthesis of Chiral 3-Arylsuccinimides by Rhodium- Catalyzed Enantioselective Conjugate Addition of Arylboronic Acids to Maleimides" Chem. Eur. J. 2015, 21, 11050 – 11055. (Hot paper and highlighted on back cover)  参考连结参考连结
  15. Balraj Gopula, Yun-Fan Tsai, Ting-Shen Kuo, Ping-Yu Wu, Julian, P. Henschke, and Hsyueh-Liang Wu " Rhodium/Chiral Diene Complexes in the Catalytic Asymmetric Arylation of beta-Pyrazole-1-yl Acrylates"
    Org. Lett. 2015, 17, 1142–1145. 参考连结参考连结
  16. Balraj Gopula, Chien-Wei Chiang, Way-Zen Lee, Ting-Shen Kuo, Ping-Yu Wu, Julian P. Henschke and Hsyueh-Liang Wu* " Highly Enantioselective Rh-Catalyzed Asymmetric Alkenylation of Imines: Synthesis of Chiral Allylic Amines via Asymmetric Addition of Potassium Alkenyltrifluoroborates fo N-Tosyl Imines " Org. Lett. 2014, 16, 632-635.
  17. Chun-Chih Chen, Balraj Gopula, Jin-Fong Syu, Jhih-Han Pan, Ting-Shen Kuo, Ping-Yu Wu, Julian P. Henschke and Hsyueh-Liang Wu* " Enantioselective and Rapid Rh-Catalyzed Arylation of N-Tosyl and N-Nosylaldimines in Methanol" J. Org. Chem. 2014, 79, 8077-8085.
  18. Yedukondalu Meesala, Hsyueh-Liang Wu, Bommisetti Koteswararao, Ting-Shen Kuo, and Way-Zen Lee* "Aerobic Oxidative Coupling of 2‐Naphthol Derivatives Catalyzed by a Hexanuclear Bis(μ-hydroxo)copper(II) Catalyst" Organometallics, 2014, 33, 4385–4393
    参考连结参考连结
  19. Kung-Chih Huang, Balraj Gopula, Ting-Shen Kuo, Chien-Wei Chiang, Ping-Yu Wu, Julian P. Henschke and Hsyueh-Liang Wu* " Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to β-Nitroolefins: Formal Synthesis of (S)-SKF 38393 " Org. Lett. 2013, 15, 5730-5733.
  20. Toshiyuki Moriuchi ,  Lisheng Mao ,  Hsyueh-Liang Wu ,  Satoshi D. Ohmura ,  Masami Watanabe and Toshikazu Hirao＊"Synthesis of facial cyclometalated iridium(III) complexes triggered by tripodal ligands" DALTON TRANSACTIONS , 2012, 41, 9519-9525.
  21. Balraj Gopula, Way-Zen Lee, and Hsyueh-Liang Wu* "Preparation of Chiral alpha-Substituted Alaninates through an Efficient Diastereoselective Synthesis of Trisubstituted Allylic Alcohols" Chem. Asian J. 2013, 8, 80-83. -Most Accessed from Jan/2013-Sep/2013
  22.  Ying-Ni Cheng, Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang* “Enantioselective Addition of Dialkylzincs to Aldehydes Catalyzed by (-)-MITH“ Chem. Asian. J. 2012, 7, 2921-2924.
  23. Yu-Chiang, Chung, Damodar Janmanchi and Hsyueh-Liang Wu* " Preparation of Chiral 3-Aryl Pyrrolidines via the Enantioselective 1,4-Addition of Arylboronic Acids to Fumaric Esters Catalyzed by Rh(I)/Chiral Diene Complexes." Org. Lett. 2012, 14, 2766-2769. 
  24. Chia-Chen Liu, Damodar Janmanchi, Chun-Chih Chen, Hsyueh-Liang Wu* “Expanding C1-Symmetric Bicyclo[2.2.1]heptadiene Ligand Family: Highly Enantioselective Synthesis of Cyclic b-Aryl Substituted Carbonyl Compounds.” Eur. J. Org. Chem. 2012, 2503-2507. 
  25. Wei-Ting Wei, Jiann-Yih Yeh, Ting-Shen Kuo, Hsyueh-Liang Wu* "Highly Enantioselective Rhodium-Catalyzed Asymmetric 1,4-Addition Reactions of Arylboronic Acids to Acyclic a,b-Unsaturated Compounds: The Formal Synthesis of (-)-Indatraline" Chem. Eur. J. 2011, 17, 11405-11409. 
  26. Ping-Yu Wu, Hsyueh-Liang Wu, Ying-Ying Shen, Biing-Jiun Uang “Asymmetric Synthesis of Propargylic Alcohols Catalyzed by (-)-MITH” Tetrahedron: Asymmetry 2009, 20, 1837-1841. 
  27. Zhi-Long Wu, Hsyueh-Liang Wu, Ping-Yu Wu, Biing-Jiun Uang “Asymmetric Addition of Diethylzinc to Aldehydes Catalyzed by a Camphor-Derived β-Amino Alcohol” Tetrahedron: Asymmetry 2009, 20, 1556-1560.
  28. Hsyueh-Liang Wu, Ping-Yu Wu, Biing-Jiun Uang “ Asymmetric Addition of Dimethylzinc to α-Ketoesters Catalyzed by (-)-MITH.” J. Org. Chem. 2008, 73, 6445-6447.
  29. Mei-Chi Chang, Hsyueh-Liang Wu, Chiu-Po Chan, Biing-Jiun Uang, Chia-Shan Lee, Bor-Dong Chen, Bor-Ru Lin, Hsiao-Hwa Chang, Chen-Jie Kao, Jiiang-Huei Jeng “Antithrombotic Effect of Hydroxychavicol, a Novel Betel Leaf Component: Role of Cyclooxygenase, Reactive Oxygen Species and Calcium Mobilization” British Journal of Pharmacology 2007, 152, 73-82. 
  30. Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang “ Highly enantioselective synthesis of (E)-allylic alcohols” J. Org. Chem. 2007, 72, 5935-5937 
  31. Toru Amaya, Koichi Mori, Hsyueh-Liang Wu, Satoshi Ishida, Jun-ichi Narkamura, Kazuhiko Murata, Toshikazu Hirao. “Synthesis and Characterization of π-extended Bowl-shaped π-Conjugated Molecules.” Chem. Commun. 2007, 1902-1904. 
  32. Ping-Yu Wu, Hsyueh-Liang Wu, and Biing-Jiun Uang, “Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ-Amino Thiol.” J. Org. Chem. 2006, 71, 833-835.
  33. Post-Conference of 1st International Conference on Cutting Edge Organic Chemistry in Asia, Oct 21-24, 2006, National Tsing Hua University, Hsinchu, Taiwan, Presentation Titles: (a) Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ−Amino Thiol (Best Poster Award) Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang (b) The Effects of Sulfur and Oxygen Atoms of the Ligands in the Addition Reaction of Dialkylzinc to Aldehydes Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang 
  34. J. H. Jeng,Y. J. Wang, W. H. Chang, H. L. Wu, C. H. Li, B. J. Uang, J. J. Kang, J. J. Lee, L. J. Hahn, B. R. Lin, and M. C. Chang "Reactive Oxygen Species are Crucial for Hydroxychavicol Toxicity Toward KB Epithelial Cells" Cellular and Molecular Life Sciences, 2004, 61, 83-96.
  35. Hsyueh-Liang Wu and Biing-Jiun Uang “Asymmetric Epoxidation of Allylic Alcohols Catalyzed by New Chiral Vanadium (V) Complexes”. Tetrahedron: Asymmetry 2002, 13, 2625.
  36. M. C. Chang, B. J. Uang. H. L. Wu, J. J. Lee, L. J. Hahn, J. H. Jeng. “Inducing the cell cycle arrest and apoptosis of oral KB carcinoma cells by hydroxychavicol : roles of glutathione and reactive oxygen species” British Journal of Pharmacology 2002, 135, 619.
  1. Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang. A review article regarding “(-)-2-exo-Morpholinoisobornane-10-thiol” in e-EROS Encyclopedia of Reagents for Organic Synthesis. 
  2. Hsyueh-Liang Wu and Toshikazu Hirao. First update on “Vanadyl Bis(acetyl acetonate)” in e-EROS Encyclopedia of Reagents for Organic Synthesis.
  1. Chiral diene ligands, a fabrication method thereof and applications thereof (US 8,586,810 B2) 
  2.  METAL-CATALYZED ASYMMETRIC 1,4-CONJUGATE ADDITION OF VINYLBORON COMPOUNDS TO 2-SUBSTITUTED-4-OXY-CYCLOPENT-2-EN-1-ONES YIELDING PROSTAGLANDINS AND PROSTAGLANDIN ANALOGS (U.S. Pat. Appl. 2016/0009740 A1, 2016)
  3. 掌性双烯配体及其制备方法与应用-中华民国专利
I.  ORAL PRESENTATION
1. 2nd Workshop on Organic Chemistry for Junior Chemists (TIT-NTHU) 2002 Hsyueh-Liang Wu and Biing-Jiun Uang “Asymmetric epoxidation of allylic alcohols catalyzed by camphor derived chiral hydroxamic acids.”
2. 1st Workshop on Organic Chemistry for Junior Chemists 2003 (NTHU-Nagaoka Institute of Technology) Hsyueh-Liang Wu and Biing-Jiun Uang “Enantioselective addition of Et2Zn to aldehydes catalyzed by camphor derived chiral ligands.”
3. 4th Workshop on Organic Chemistry for Junior Chemists (2004), Tokyo Institute of Technology, Yokohama, Japan. Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang, Enantioselective Addition of Diethylzinc Reagent to Aldehydes with Camphor-Derived Ligands.
4. NTHU-KAIST 2005 Junior Chemists Workshop (2005), National Tsing Hua University, Hsinchu, Taiwan. Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang, (+)-Nonlinear Effect in Asymmetric Addition of the Diethylzinc to Aldehydes
5. 86th spring meeting. Toru Amaya, Hsyueh-Liang Wu, Koichi Mori, Toshikazu Hirao. Synthesis of p-conjugated Sumanenes.
6. 86th spring meeting. Toru Amaya, Hsyueh-Liang Wu, Satoshi Ishida, Jun-ichi Nakamura, Kazuhiko Murata, Hidehiro Sakurai, Toshikazu Hirao, Study on π- Conjugation of Bowl-shaped π-Conjugated Sumanene.
7.International Symposium on Organic Reaction 2006. Toru Amaya, Hsyueh-Liang Wu, Koichi Mori, Toshikazu Hirao. Synthesis of p-conjugated Sumanenes
8. Invited speaker in COEIEC 8 Symposium. Title: Camphor derived chiral ligands in organozincs addition to aldehydes.
9. Invited speaker in WOCJC-7 Symposium. Title: Chiral [2.2.1] Diene Ligands for Asymmetric Catalysis
II. POSTER:
1. 5th International Conference on Cutting Edge Organic Chemistry in Asia, Nov 7-11, 2010, National Tsing Hua University, Hsinchu, Taiwan, Presentation Titles: Chiral [2.2.1] Diene Ligands for Asymmetric Catalysis
2. 5th Workshop on Organic Chemistry for Junior Chemists. Nov 23-26, 2006, National Tsing Hua University, Hsinchu, Taiwan Presentation Titles: Asymmetric Catalytic Organozinc Addition Reactions Based on Camphor Derived Ligand. Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang.
3. Post-Conference of 1st International Conference on Cutting Edge Organic Chemistry in Asia, Oct 21-24, 2006, National Tsing Hua University, Hsinchu, Taiwan, Presentation Titles: (a) Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ−Amino Thiol (Best Poster Award) Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang
(b) The Effects of Sulfur and Oxygen Atoms of the Ligands in the Addition Reaction of Dialkylzinc to Aldehydes Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
4. The 8th International 21st Century COE Symposium on Integrated EcoChemistry, Aug 28-29, 2006, Osaka University, Japan Presentation Title: Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ-Amino Thiol
Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang
5. The 8th International Symposium on Organic Reactions, Apr 23-26, 2006, Kobe,Japan. Presentation Titles: Highly Enantioselective Addition of Alkenylzinc to Aldehydes Catalyzed by γ-Amino Thiol Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
6. The 10th International Chemical Conference, Taipei, Oct 28-30, 2005, National Tsing Hua University, Hsinchu, Taiwan. Presentation Titles: (a) Highly Enantioselective Addition of Alkenylzinc to Aldehydes Catalyzed by (-)- MITH
Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
(b) Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ- Amino Thiol Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang
7. Tokyo Summer School on Frontier Chemistry 2005, Aug 25-27, 2005, The University of Tokyo, Tokyo, Japan Presentation Title: Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by γ-Amino Thiol
Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang
8. NTHU-KAIST 2005 Junior Chemists Workshop, Feb 25-27, 2005, National Tsing Hua University, Hsinchu, Taiwan Presentation Title: (+)-Nonlinear Effect in Asymmetric Addition of the Diethylzinc to Aldehydes Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
9. Annual Meeting of Chinese Chemical Society, Taipei, Nov 19-20, 2005, National Sun Yat-Sen University, Kaohsiung, Taiwan Presentation Titles:
(a) Camphor-Derived Oxazolines in Asymmetic Addition of Et2Zn to Aldehydes Ming-Shau Yang, Hsyueh-Liang Wu, Ping-Yu Wu, Che-Chia Chen and Biing-Jiun Uang
(b) Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ- Amino Thiol Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang
(c) Highly Enantioselective Addition of Alkenylzinc to Aldehydes Catalyzed by (-)- MITH Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
10. 4th Workshop on Organic Chemistry for Junior Chemists, Sep 24-27, 2004, Tokyo Institute of Technology, Japan Presentation Title: Enantioselective Addition of Diethylzinc Reagent to Aldehydes with Camphor Derived Ligands
Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
11. Annual Symposium of Chinese Chemical Society 2004 a) Chih-Lung Wu, Hsyueh-Liang Wu and Biing-Jiun Uang “Enantioselective Addition of Et2Zn to Aldehydes Catalyzed by b-Amino Alcohols”.....ORS-B-089
b) Hsyueh-Liang Wu, Ping-Yu Wu and Biing Jiun Uang “ (+)-Nonlinear Effect in Asymmetric Addition of the Et2Zn to Aldehydes.” ........ ORS-B-090.
12. 3rd Workshop on Organic Chemistry for Junior Chemists (TIT-NTHU) 2004 Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang “Enantioselective addition of Et2Zn to aldehydes with camphor derived chiral ligands.”
13. Annual Symposium of Chinese Chemical Society 2003 Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang “Enantioselective addition of Et2Zn to aldehydes “..............................OR-PA-061.
14.The 7th International Symposium for Chinese Organic Chemists 2002 Hsyueh- Liang Wu and Biing-Jiun Uang “Chiral camphor based hydroxamic acid catalyzed asymmetric epoxidation of allylic alcohols”........P-058.
15. Annual Symposium of Chinese Chemical Society 2002 Hsyueh-Liang Wu and Biing-Jiun Uang “Chiral camphor based hydroxamic acid catalyzed asymmetric epoxidation of allylic alcohols”........P-OR-072.
16. 2nd Workshop on Organic Chemistry for Junior Chemists (TIT-NTHU) 2002 Hsyueh-Liang Wu and Biing-Jiun Uang “Asymmetric epoxidation of allylic alcohols catalyzed by camphor derived chiral hydroxamic acids.”
17. 1st Workshop on Organic Chemistry for Junior Chemists 2002 (NTHU-Shanghai Institute of Organic Chemistry) Hsyueh-Liang Wu and Biing-Jiun Uang “Asymmetric epoxidation of allylic alcohols catalyzed by camphor derived chiral hydroxamic acids.”
18. 3rd International Symposium on Chemistry and Chemical Biology of Vanadium at Osaka Japan 2001 Hsyueh-Liang Wu and Biing-Jiun Uang “Asymmetric epoxidation of allylic alcohols catalyzed by camphor derived chiral hydroxamic acids.