葉怡均
姓名 葉怡均
電子郵件
聯絡電話 02-77496117
實驗室電話 02-77496211
職稱 特聘教授
研究領域 生物化學、合成生物學、生物能源、生物感測器
指導學生 張祐嘉 王存多 陳姵妤 袁佳璟 張宇承 劉曉潔
 
實驗室 生物有機化學研究室C407

學術著作

    1. S. Kulandaivel, H.-T. Chen*, C.-H. Lin* and Y.-C. Yeh* Exploring the potential of iron-based metal–organic frameworks as peroxidase nanozymes for glucose detection with various secondary building units Journal of Materials Chemistry B 2023 DOI: 10.1039/D3TB00981E
    2. Lee M.-J., Chang Y.-J., Cheng C.-J., Yeh, Y.-C.*, Chen C.-F*, Chou Y.-J. *, A theoretical framework to determine the optimal centrifugation angle for separation of plasma from blood samples, Sensors and Actuators A: Physical 2023, 353, 114234.
    3. Shin Lu S. S., Lai Y.-R., Hsiao L.-H., Huang H.-Y., Tsai Y.-H., Chen Y, Wang S.-S. *, Yeh, Y.-C.*, Tsai S.-L.*, Effects of amino acid-functionalized silver nanoparticles on lysozyme amyloid fibrillogenesis, Colloids and Surfaces B: Biointerfaces 2023, 222,113144,
    4. Kulandaivel, S.; Lin, C.-H.; Yeh, Y.-C*., A bioinspired copper-based coordination polymer for the detection of pheochromocytoma biomarkers. Talanta 2022, 12420
    5. Zaki, M. F.;  Chen, P.-C*.; Yeh, Y.-C*.;  Lin, P.-H.; Xu, M.-Y., Engineering A Monolithic 3D Paper-Based Analytical Device (μPAD) by Stereolithography 3D Printing and Sequential Digital Masks for Efficient 3D Mixing and Dopamine Detection. Sensors and Actuators A: Physical 2022, 113991.
    6. Chang, C.-W.;  Lin, Y.-H.;  Tsai, C.-H.;  Kulandaivel, S.; Yeh, Y.-C*., Sequential detection of dopamine and L-DOPA by a 2, 3-dopa-dioxygenase from Streptomyces sclerotialus. Analytica Chimica Acta 2022, 1202, 339641
    7. Kulandaivel, S.;  Lo, W.-C.;  Lin, C.-H. *; Yeh, Y.-C*., Cu-PyC MOF with oxidoreductase-like catalytic activity boosting colorimetric detection of Cr (VI) on paper. Analytica Chimica Acta 2022, 1227, 340335.
    8. Kulandaivel, S.;  Lin, C.-H*.; Yeh, Y.-C*., The bi-metallic MOF-919 (Fe–Cu) nanozyme capable of bifunctional enzyme-mimicking catalytic activity. Chemical Communications 2022, 58 (4), 569-572.
    9. Tsai, S. T.;  Cheng, W. J.;  Zhang, Q. X.; Yeh, Y.-C*., Gold-Specific Biosensor for Monitoring Wastewater Using Genetically Engineered Cupriavidus metallidurans CH34. ACS Synth Biol 2021, 10 (12), 3576-3582.
    10. Chen, P.-C.;  Chen, K.-H.;  Lin, C.-Y.; Yeh, Y.-C*., Rapidly and simultaneously quantifying multiple biomarkers of L-tyrosine hydroxylase deficiency by using paper microfluidic devices and smartphone-based analysis system. Sensors and Actuators B: Chemical 2021, 349.
    11. Lin, Y. H.; Yeh, Y.-C*., Rapid synthesis of microwave-assisted zinc oxide nanorods on a paper-based analytical device for fluorometric detection of l-dopa. Colloids Surf B Biointerfaces 2021, 207, 111995.
    12. Hsu, L. W.; Lin, Y. H.; Guo, J. Y.; Chen, C. F.; Chou, Y. J.; Yeh, Y.-C*., SimultaneousDetermination of l-Phenylalanine, Phenylethylamine, and PhenylaceticAcid Using Three-ColorWhole-Cell Biosensors within a Microchannel Device.ACS Appl Bio Mater 2020,3(8),5120-5125
    13. Shih, C. I.;  Chou, Y. C.;  Chen, H. Y.;  Chen, K. H.;  Wang, I. H.; Yeh, Y.-C*, Colorimetric and Fluorometric Paper-Based Assay for Cu(2+) Detection Based on Green Synthesis of 2-Aminoterephthalic Acid-Derived Pigments. ACS Appl Bio Mater 2020, 3 (4), 2516-2521.
    14. Chou, Y.-C.;  Shih, C.-I.;  Chiang, C.-C.;  Hsu, C.-H.; Yeh, Y.-C*., Reagent-free DOPA-dioxygenase colorimetric biosensor for selective detection of L-DOPA. Sensors and Actuators B: Chemical 2019, 297.
    15. Liu, C.-Y.;  Chou, Y.-C.;  Tsai, J.-H.;  Huang, T.-M.;  Chen, J.-Z*.; Yeh, Y.-C*, Tyrosinase/Chitosan/Reduced Graphene Oxide Modified Screen-Printed Carbon Electrode for Sensitive and Interference-Free Detection of Dopamine. Applied Sciences 2019, 9 (4).
    16. Lu, K. H.;  Lin, J. H.;  Lin, C. Y.;  Chen, C. F*.; Yeh, Y.-C*., A fluorometric paper test for chromium(VI) based on the use of N-doped carbon dots. Mikrochim Acta 2019, 186 (4), 227.
    17. Lin, C.;  Zhang, Q.-X.; Yeh, Y.-C*, Development of a whole-cell biosensor for the determination of tyrosine in urine for point-of-care diagnostics. Analytical Methods 2019, 11 (10), 1400-1404.
    18. Guo, K. H.;  Chen, P. H.;  Lin, C.;  Chen, C. F.;  Lee, I. R.; Yeh, Y.-C*, Determination of Gold Ions in Human Urine Using Genetically Engineered Microorganisms on a Paper Device. ACS Sens 2018, 3 (4), 744-748.
    19. Chen, Y.-J.;  Liu, C.-Y.;  Tsai, D.-Y.; Yeh, Y.-C*, A portable fluorescence resonance energy transfer biosensor for rapid detection of silver ions. Sensors and Actuators B: Chemical 2018, 259, 784-788.
    20. Lin, C.;  Jair, Y. C.;  Chou, Y. C.;  Chen, P. S.; Yeh, Y.-C*., Transcription factor-based biosensor for detection of phenylalanine and tyrosine in urine for diagnosis of phenylketonuria. Anal Chim Acta 2018, 1041, 108-113.
    21. Guo, K. H.;  Lu, K. H.; Yeh, Y.-C*, Cell-Based Biosensor with Dual Signal Outputs for Simultaneous Quantification of Phenylacetic Acid and Phenylethylamine. ACS Synth Biol 2018, 7 (12), 2790-2795.
    22. Lin, Y.K.; Yeh, Y.-C*., Dual-Signal Microbial Biosensor for the Detection of Dopamine without Inference from Other Catecholamine Neurotransmitters. Anal Chem 2017,89(21), 11178-11182.
    23. Chen, P.-H.;  Lin, C.;  Guo, K.-H.; Yeh, Y.-C*, Development of a pigment-based whole-cell biosensor for the analysis of environmental copper. RSC Advances 2017, 7 (47), 29302-29305.
    24. Yang, C.-H.;  Chen, C.-W.;  Lin, Y.-K.;  Yeh, Y.-C.;  Hsu, C.-C.;  Fan, Y.-J.;  Yu, I.-S.; Chen, J.-Z., Atmospheric-Pressure Plasma Jet Processed Carbon-Based Electrochemical Sensor Integrated with a 3D-Printed Microfluidic Channel. Journal of The Electrochemical Society 2017, 164 (12), B534-B541.
    25. Ouyang, C.-Y.;  Lin, Y.-K.;  Tsai, D.-Y.; Yeh, Y.-C*., Secretion of metal-binding proteins by a newly discovered OsmY homolog in Cupriavidus metallidurans for the biogenic synthesis of metal nanoparticles. RSC Advances 2016, 6 (20), 16798-16801.
    26. Tsai, D.-Y.;  Tsai, Y.-J.;  Yen, C.-H.;  Ouyang, C.-Y.; Yeh, Y.-C*., Bacterial surface display of metal binding peptides as whole-cell biocatalysts for 4-nitroaniline reduction. RSC Advances 2015, 5 (107), 87998-88001.
    27. Tseng, H. W.;  Tsai, Y. J.;  Yen, J. H.;  Chen, P. H.; Yeh, Y. C*., A fluorescence-based microbial sensor for the selective detection of gold. Chem Commun (Camb) 2014, 50 (14), 1735-7.
    28. Yeh, Y. C.;  Muller, J.;  Bi, C.;  Hillson, N. J.;  Beller, H. R.;  Chhabra, S. R.; Singer, S. W. *, Functionalizing bacterial cell surfaces with a phage protein. Chem Commun (Camb) 2013, 49 (9), 910-2.
    29. Goley, E. D.; Yeh, Y. C.;  Hong, S. H.;  Fero, M. J.;  Abeliuk, E.;  McAdams, H. H.; Shapiro*, L., Assembly of the Caulobacter cell division machine. Mol Microbiol 2011, 80 (6), 1680-98.
    30. Yeh, Y. C.;  Comolli, L. R.;  Downing, K. H.;  Shapiro, L.; McAdams, H. H*., The caulobacter Tol-Pal complex is essential for outer membrane integrity and the positioning of a polar localization factor. J Bacteriol 2010, 192 (19), 4847-58.
    31. Lin, C. C.;  Yeh, Y. C.;  Yang, C. Y.;  Chen, G. F.;  Chen, Y. C.;  Wu, Y. C.; Chen, C. C. *, Quantitative analysis of multivalent interactions of carbohydrate-encapsulated gold nanoparticles with concanavalin A. Chem Commun (Camb) 2003,  (23), 2920-1.
    32. Lin, C. C.;  Yeh, Y. C.;  Yang, C. Y.;  Chen, C. L.;  Chen, G. F.;  Chen, C. C.; Wu, Y. C. *, Selective binding of mannose-encapsulated gold nanoparticles to type 1 pili in Escherichia coli. J Am Chem Soc 2002, 124 (14), 3508-9.
年度 論文名稱
2024 Defect Induced Structural Transition and Lipase Immobilization in Mesoporous Aluminum Metal-Organic Frameworks, Chemistry-A European Journal, May. 2024
2023 Recent advances in the biological depolymerization and upcycling of polyethylene terephthalate, Current Opinion in Biotechnology, vol. 85, Dec. 2023
2023 Harnessing split fluorescent proteins in modular protein logic for advanced whole-cell detection, Analytica Chimica Acta, vol. 1275, Sep. 2023
2023 Exploring the Potential of Non-porous Iron-Based Metal-Organic Frameworks as Peroxidase Nanozymes for Glucose Detection, Journal of Materials Chemistry B, Jul. 2023
2023 A theoretical framework to determine the optimal centrifugation angle for separation of plasma from blood samples, Sensors and Actuators A: Physical, vol. 353, Apr. 2023
2023 A bioinspired copper-based coordination polymer for the detection of pheochromocytoma biomarker, Talanta, vol. 255, Apr. 2023
2023 Effects of amino acid-functionalized silver nanoparticles on lysozyme amyloid fibrillogenesis, Colloids and Surfaces B: Biointerfaces, vol. 222, Feb. 2023
2022 Engineering a monolithic 3D paper-based analytical device (μPAD) by stereolithography 3D printing and sequential digital masks for efficient 3D mixing and dopamine detection, Sensors and Actuators A: Physical, vol. 347, Nov. 2022
2022 Cu-PyC MOF with oxidoreductase-like catalytic activity boosting colorimetric detection of Cr(VI) on paper, Analytica Chimica Acta, vol. 1227, Aug. 2022
2022 Sequential Detection of Dopamine and L-DOPA by a 2,3-dopa-dioxygenase from Streptomyces sclerotialus, Analytica Chimica Acta, Feb. 2022
2022 Bi-metallic MOF-919 (Fe-Cu) nanozyme capable of bifunctional enzyme-mimicking catalytic activity, Chemical Communications, vol. DOI: 10.1039/D1CC05908D, Jan. 2022
2021 Gold-specific biosensor for monitoring wastewater using genetically engineered Cupriavidus metallidurans CH34, ACS Synthetic Biology, Dec. 2021
2021 Rapidly and Simultaneously Quantifying Multiple Biomarkers of L-tyrosine Hydroxylase Deficiency by Using Paper Microfluidic Devices and Smartphone-Based Analysis System., Sensors and Actuators: B. Chemical, vol. 349, Sep. 2021
2021 Rapid synthesis of microwave-assisted zinc oxide nanorods on a paper-based analytical device for fluorometric detection of L-dopa., Colloids and Surfaces B: Biointerfaces, vol. 207, Jul. 2021
2020 Simultaneous Determination of L-phenylalanine, Phenylethylamine, and Phenylacetic Acid Using Three-Color Whole-Cell Biosensors within a Microchannel Device, ACS Applied Bio Materials, vol. 3, Jul. 2020
2020 Detection of tyrosine and monitoring tyrosinase activity using an enzyme cascade-triggered colorimetric reaction, RSC Advances, vol. 10, Jul. 2020
2020 Simultaneous Determination of L-phenylalanine, Phenylethylamine, and Phenylacetic Acid Using Three-Color Whole-Cell Biosensors within a Microchannel Device, ACS Applied Bio Materials, vol. 3, Jul. 2020
2020 Colorimetric and Fluorometric Paper-Based Assay for Cu2+ Detection Based on Green Synthesis of 2-Aminoterephthalic Acid-Derived Pigments, ACS Appl. Bio Mater., vol. 3, Apr. 2020
2019 Reagent-free DOPA-dioxygenase Colorimetric Biosensor for Selective Detection of L-DOPA, Sensors & Actuators: B. Chemical, vol. 297, Jun. 2019
2019 Tyrosinase/Chitosan/Reduced Graphene Oxide Modified Screen-Printed Carbon Electrode for Sensitive and Interference-Free Detection of Dopamine, Applied Sciences, vol. 9, Feb. 2019
2019 Development of a Whole-cell Biosensor for the Determination of Tyrosine in Urine for Point-of-care Diagnostics, Analytical methods, vol. 10, Feb. 2019
2019 A fluorometric paper test for chromium(VI) based on the use of N-doped carbon dots, Microchimica Acta, vol. 186, Jan. 2019
2018 Cell-based biosensor with dual signal outputs for simultaneous quantification of phenylacetic acid and phenylethylamine, ACS Synthetic Biology, vol. 7, Nov. 2018
2018 Transcription Factor-Based Biosensor for Detection of Phenylalanine and Tyrosine in Urine for Diagnosis of Phenylketonuria., Analytica Chimica Acta, vol. 1041, Aug. 2018
2018 A portable fluorescence resonance energy transfer biosensor for rapid detection of silver ions, Sensors and Actuators, B: Chemical, vol. 259, Apr. 2018
2018 A portable fluorescence resonance energy transfer biosensor for rapid detection of silver ions, Sensors and Actuators, B: Chemical, vol. 259, Apr. 2018
2018 Determination of Gold Ions in Human Urine Using Genetically Engineered Microorganisms on a Paper Device, ACS sensors, vol. 3, Feb. 2018
2017 Dual-Signal Microbial Biosensor for the Detection of Dopamine without Inference from Other Catecholamine Neurotransmitters., Analytical chemistry, vol. 89, Oct. 2017
2017 Using Fluorescence Resonance Energy Transfer for Bioimaging Applications, CHEMISTRY (The Chinese Chemical Society, Taipei), vol. 75, Aug. 2017
2017 Atmospheric-Pressure Plasma Jet Processed Carbon-Based Electrochemical Sensor Integrated with a 3D-Printed Microfluidic Channel, Journal of The Electrochemical Society, vol. 164, Aug. 2017
2017 Development of a pigment-based whole-cell biosensor for the analysis of environmental copper, RSC advances, vol. 7, May. 2017
2017 Development of a pigment-based whole-cell biosensor for the analysis of environmental copper, RSC Advances, vol. 7, Jan. 2017
2016 Secretion of metal-binding proteins by a newly discovered OsmY homolog in Cupriavidus metallidurans for the biogenic synthesis of metal nanoparticles, RSC Advances, vol. 6, Feb. 2016
2016 Secretion of metal-binding proteins by a newly discovered OsmY homolog in Cupriavidus metallidurans for the biogenic synthesis of metal nanoparticles, RSC Advances, vol. 6, Jan. 2016
2015 Bacterial surface display of metal binding peptides as whole-cell biocatalysts for 4-nitroaniline reduction, RSC advances, vol. 5, Oct. 2015
2015 One-step synthesis of water-soluble fluorescent copper nanoparticles for label-free detection of manganese ions, Analytical Methods, vol. 7, Aug. 2015
2015 One-step synthesis of water-soluble fluorescent copper nanoparticles for label-free detection of manganese ion, Analytical methods, vol. 7, Aug. 2015
2015 Bacterial surface display of metal binding peptides as whole-cell biocatalysts for 4-nitroaniline reduction, RSC Advances, vol. 5, Jan. 2015
2014 Biosynthesis and display of diverse metal nanoparticles by recombinant Escherichia coli, RSC Advances, vol. 4, Nov. 2014
2014 Biosynthesis and display of diverse metal nanoparticles by recombinant Escherichia coli, RSC Advances, vol. 4, Oct. 2014
2014 Engineering of Ralstonia eutropha H16 for Autotrophic and Heterotrophic Production of Methyl Ketones, Applied and Environmental Microbiology, vol. 79, Jul. 2014
2014 A fluorescence-based microbial sensor for the selective detection of gold, Chemical Communications, vol. 50, Feb. 2014
2014 A fluorescence-based microbial sensor for the selective detection of gold, Chem. commun., vol. 50, Jan. 2014
2013 Development of a broad-host synthetic biology toolbox for ralstonia eutropha and its application to engineering hydrocarbon biofuel production, Microbial Cell Factories, vol. 12, Nov. 2013
2013 Development of a broad-host synthetic biology toolbox for ralstonia eutropha and its application to engineering hydrocarbon biofuel production, Microbial Cell Factories, vol. 12, Nov. 2013
2013 Engineering of Ralstonia eutropha H16 for autotrophic and heterotrophic production of methyl ketones, Applied and Environmental Microbiology, vol. 79, Jul. 2013
2013 Functionalizing bacterial cell surfaces with a phage protein, Chemical Communications, vol. 49, Jan. 2013
2013 Functionalizing Bacterial Cell Surfaces with a Phage Protein, Chemical Communications, vol. 49, Jan. 2013
2011 Assembly of the Caulobacter cell division machine, Molecular Microbiology, vol. 80, Jun. 2011
2011 Assembly of the Caulobacter cell division machine., Mol. Microbiol., vol. 80, May. 2011
2010 The Caulobacter Tol-Pal complex is essential for outer membrane integrity and the positioning of a polar localization factor, Journal of Bacteriology, vol. 192, Oct. 2010
2010 The Caulobacter Tol-Pal complex is essential for outer membrane integrity and is required for the completion of cell division and polar protein localization., J. Bacteriol, vol. 192, Aug. 2010
2003 Quantitative analysis of multivalent interactions of carbohydrate- encapsulated gold nanoparticles with concanavalin A, Chemical Communications, vol. 9, Dec. 2003
2003 Quantitative analysis of multivalent interactions of carbohydrate-encapsulate gold nanoparticle with concanavalin A, Chem. Commun., vol. 23, Jan. 2003
2002 Selective binding of mannose-encapsulated gold nanoparticles to type 1 pili in Escherichia coli, Journal of the American Chemical Society, vol. 124, Apr. 2002
2002 Selective binding of mannose-encapsulated gold nanoparticles to type 1 pili in Escherichia coli., J. Am. Chem. Soc., vol. 124, Jan. 2002
年度 論文名稱
2012 Tethering Hydrogen-­‐Producing Catalysts to the Outer Membrane of Biofuel-­‐Producing Ralstonia eutropha H16, ASM general meeting, Jun. 16-Dec. 19, 2012, San Francisco
年度 計畫名稱 職稱/擔任之工作 計畫期間 補助/委託或合作機構
2024 以邏輯閘運算開發全細胞生物傳感器用於中樞神經系統興奮劑之探討(1/3) 總主持人 2023.08 ~ 2024.07 國科會
2023 多巴雙加氧酶: 性質鑑定與分析上的應用(2/2) 總主持人 2022.08 ~ 2023.07 國科會
2022 多巴雙加氧酶: 性質鑑定與分析上的應用(1/2) 總主持人 2021.08 ~ 2022.07 國科會
2021 以全細胞試紙呈色發展苯酮尿症偵測工具 總主持人 2020.08 ~ 2021.07 國科會
2020 以全細胞試紙呈色發展苯酮尿症偵測工具 總主持人 2019.08 ~ 2020.07 國科會
2019 以全細胞試紙呈色發展苯酮尿症偵測工具 主持人 2018.08 ~ 2019.07 科技部(原國科會)
2018 生物色素感測器於金屬檢測之開發與研究 主持人 2017.08 ~ 2018.07 科技部(原國科會)
2017 生物色素感測器於金屬檢測之開發與研究 主持人 2016.08 ~ 2017.07 科技部(原國科會)
2016 奈米材料之生物合成與回收 主持人 2015.08 ~ 2016.07 國科會
2015 奈米材料之生物合成與回收 主持人 2014.08 ~ 2015.07 國科會
2014 以細菌之信息傳遞設計新一代生物感測器與細胞表面展示技術 主持人 2013.08 ~ 2014.07 國科會
2013 以細菌之信息傳遞設計新一代生物感測器與細胞表面展示技術 主持人 2012.11 ~ 2013.07 國科會
國家 學校名稱 系所 學位 期間
美國 史丹佛大學 化學系 博士 2004.09 ~ 2010.12
台灣 國立台灣師範大學 化學系 碩士 2001.09 ~ 2003.06
台灣 國立台灣師範大學 化學系 學士 1997.09 ~ 2001.06
服務機關名稱 單位 職務 期間
國立台灣師範大學 化學系 教授 2019.08 ~ 0000.01
國立台灣師範大學 化學系 副教授 2016.02 ~ 2019.07
國立台灣師範大學 化學系 助理教授 2012.08 ~ 2016.01
勞倫斯柏克萊國家實驗室 物理生物所 博士後研究員 2011.01 ~ 2012.07