姚清發
姓名 姚清發
電子郵件 cheyaocf@ntnu.edu.tw
聯絡電話 (02)77496128
個人網址 http://140.122.142.231/~cheyaocf/Yao/
實驗室電話 (02)77496156
職稱 特聘教授
研究領域 物理有機化學、有機合成
學術專長 研究興趣 探討β-硝基苯乙烯和各種試劑之反應機構和開發新的合成方法
實驗室 物理有機研究室

學術著作

  1.  143. Ni, Y.-L.; Hsieh, C.‑H.; Kim, S.‑H.; Wang, J.‑P.; Su, C.-L.; Yao, C.-F.; Fang,  K.  Apoptosis 201722(10), 1235-1245. (10) (Biochemistry & Molecular Biology 87/286; Cell Biology 75/199, 2016 IF: 3.833; 5 year impact factor: 3.704) ISSN: 1360-8185 (Print) 1573-675X (Online)A potent indolylquinoline alleviates growth of human lung cancer cell tumorspheres
    計畫編號: NSC-103-2113-M-003-008-MY3
     
    142. Bandi, V.; Kavala, V.; Hsu, C.-H.; Konala, A.; Villuri, B. K.; Kotipalli, T.; Kuo, C.-W.; Yao, C.-F.* RSC Adv. 20177(74), 46704-46712. (10) (Chemistry, Multidisciplinary: 59/165, 2016 IF: 3.226; 5 year impact factor: 3.482) Online ISSN: 2046-2069
    Synthesis of functionalized unsymmetrical 1,3-butadiene-3-yne derivatives from β-halo styrene derivatives and its application for the synthesis of trisubstituted pyridines
    計畫編號: NSC-103-2113-M-003-008-MY3
     
    141. Villuri, B. K.; Konala, A.; Kavala, V.; Kotipalli, T.; Yao, C.-F.* Adv. Synth. Catal. 2017359(18), 3142-3153. (9) (Applied Chemistry: 2/72 or Organic Chemistry: 4/59, 2016 IF: 5.646; 5 year impact factor: 5.229) Online ISSN: 1615-4169
    Copper Catalyzed Cascade Approach for the Synthesis of Dibenzo1,8-naphthyridine Derivatives
    計畫編號: NSC-103-2113-M-003-008-MY3
     
    140. Kavala, V.; Yang, Z.; Konala, A.; Huang, C.-Y.; Kuo, C.-W.; Yao, C.-F.* J. Org. Chem. 201782(14), 7280-7286. (7) (Organic Chemistry: 8/59, 2016 IF: 4.849; 5 year impact factor: 4.425) Online ISSN: 1520-6904
    Synthesis of benzofusedpyridoindolone derivatives via one-pot copper catalyzed tandem reaction of 2-iodobenzamide derivatives and 2-iodobenzylcyanides
    計畫編號: NSC-103-2113-M-003-008-MY3
     
    139. Su, C.-L.*; Tseng, C.-L.; Ramesh, C.; Liu, H.-S.; Huang, C.-Y. F.*; Yao, C.-F.* Eur. J. Med. Chem. 2017, 132, 90-107 (3) (Medicinal Chemistry: 4/60, 2016 IF: 4.519; 5 year impact factor: 4.187) Online ISSN: 0223-5234
    Using gene expression database to uncover biology functions of 1,4-disubstituted 1,2,3-triazole analogues synthesized via a copper (I)-catalyzed reaction
    計畫編號: NSC-103-2113-M-003-008-MY3
     
    138. Huang, C.-Y.; Kavala, V.; Kuo, C.-W.; Konala, A.; Yao, C.-F.* J. Org. Chem. 201782(4), 1961-1968. (2) (Organic Chemistry: 8/59, 2016 IF: 4.849; 5 year impact factor: 4.425) Online ISSN: 1520-6904
    Concise Synthesis of Biologically Active Indenoisoquinoline Derivatives via A One-Pot Copper(II)-Catalyzed Tandem Reaction
    計畫編號: NSC-103-2113-M-003-008-MY3
     
    137. Yang, T.-H.; Kuo, C.-W.; Kavala, V.; Konala, A.; Huang, C-Y.; Yao, C.-F* Chem. Commun. 2017, 53(10), 1676-1679. (2) (Chemistry, Multidisciplinary: 23/165, 2016 IF: 6.319; 5 year impact factor: 6.238) Online ISSN: 1359-7345
    Regioselective Switching Approach for the Synthesis of α and δ Carboline Derivatives
    計畫編號: NSC-103-2113-M-003-008-MY3
     
    136. Ichake, S. S.; Konala, A.; Kavala, V.; Kuo, C.-W.; Yao, C.-F.* Organic Letters  201719(1), 54-57. (1) (Organic Chemistry: 3/59, 2016 IF: 6.579; 5 year impact factor:5.836) Online ISSN: 1099-0690
    Palladium-Catalyzed Tandem CH Functionalization/Cyclization Strategy for the Synthesis of 5-Hydroxybenzofuran Derivatives
    計畫編號: NSC-103-2113-M-003-008-MY3 
  2. 135. Chang, K.-H.; Lin, C.-H.; Chen, H.-C.; Huang, H.-Y.; Chen, S.-L.; Lin, T.-H.; Ramesh, C.; Huang, C.-C.; Fung, H.-C.; Wu, Y.-R.; Huang, H.-J.; Lee-Chen, G. J.*; Hsieh-Li, H. M.*; Yao, C.-F.* CNS Neuroscience & Therapeutics 2016, 22(x), xxxx-xxxx. (x) (Pharmacology & Pharmacy: 42/253 or Neuroscience: 65/256, 2015 IF: 4.018; 5 year impact factor: 4.089) Online ISSN: 1755-5930
    The Potential of Indole/Indolylquinoline Compounds in Tau Misfolding Reduction by Enhancement of HSPB1          
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    134. Liu, C.-Y.; Hsieh, C.-H.; Kim, S.-H.; Wang, J.-P.; Ni, Y.-L.; Su, C.-L.; Yao, C.-F.; Fang, K.* International Journal of Oncology 201649 (xx), 2031-2041. (x) (Oncology: 100/213, 2015 IF: 3.018; 5 year impact factor: 2.990) Online ISSN: 1791-2423
    An indolylquinoline derivatives activates DNA damage resoponse and apotosis in human hepatocellular carcinoma cells
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    133. Huang, C.-Y.; Kuo, C.-W.; Konala, A.; Yang, T.-H.; Lin, L.; Chen, Y.-.; Kavala, V.; Yao, C.-F.* RSC Adv. 20166 (98), 96049-96056. (10) (Chemistry, Multidisciplinary: 49/163, 2015 IF: 3.289; 5 year impact factor: 3.485) Online ISSN: 2046-2069
    Synthesis of 3-arylindole derivatives from nitroalkane precursors
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    132. Chang, H. H.; Lee, L.-H.; Leong, W.-Y.; Yang, T.-C.; Yao, C.-F.; Fang, K.Drug Design, Development and Therapy 2016, 10, 2947-2957. (9) (Pharmacology & Pharmacy 84/255, 2014 IF: 2.881; 5 year impact factor: 2.962Online ISSN: 1177-8881
    A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    131. Villuri, B. K.; Kotipalli, T.; Kavala, V.; Ichake, S. S.; Bandi, V. ; Kuo, C.-W.; Yao, C.-F.* RSC Adv. 20166 (78), 74845-74858. (8) (Chemistry, Multidisciplinary: 49/163, 2015 IF: 3.289; 5 year impact factor: 3.485) Online ISSN: 2046-2069
    Synthesis of Spiro Isoindolinone-indolines and 1,2-Disubstituted Indoles from 2-Iodobenzamide Derivatives 
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    130. Kotipalli, T.;  Kavala, V.; Ashok konala, A.;  Janreddy, D.; Kuo, C.-W.; Yao, C.-F.* Adv. Synth. Catal. 2016, 358(16), 2652-2660. (8) (Applied Chemistry: 1/72 or Organic Chemistry: 5/59, 2015 IF: 6.453; 5 year impact factor: 5.852) Online ISSN: 1615-4169 (Times Cited: 1)
    Reagent/Substituent Switching Approach for the Synthesis of Substituted 1,3,4-Oxadiazole/1,3,4-Oxadiazoline and 1,2,4-Triazole Derivatives from N-Substituted Hydrazides
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    129. Kuo, C.-W.; Konala, A.; Lin, L.; Chiang, T.-T.; Huang, C-Y.; Yang, T-H .; Kavala, V.; Yao, C.-F* Chem. Commun. 2016, 52(50), 7870-7873. (6) (Chemistry, Multidisciplinary: 21/163, 2015 IF: 6.567; 5 year impact factor:6.628) Online ISSN: 1359-7345
    Synthesis of Benzo[a]carbazole derivatives from 3-Ethylindoles by Exploiting the Dual Character of Benzoquinone as an oxidizing agent and Dienophile
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    128. Huang, C.-Y.; Kuo, C.-W.; Kavala, V.; Yao, C.-F* Eur. J. Org. Chem. 2016, (15), 2720-2734. (5) (Organic Chemistry: 17/59, 2015 IF: 3.068; 5 year impact factor:2.971) Online ISSN: 1099-0690
    Syntheses of 2-benzylbenzofuran derivatives and 2-arylnitrochroman derivatives from nitroalkene precursors
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    127. Kotipalli, T.; Kavala, V.; Janreddy, D.; Bandi, V.; Kuo, C.-W.; Yao, C.-F*
    Eur. J. Org. Chem. 2016, (6), 1182-1193. (2) (Organic Chemistry: 17/59, 2015 IF: 3.068; 5 year impact factor: 2.971) Online ISSN: 1099-0690 (Times Cited:2)
    Synthesis of 2,3-Disubstituted Quinazolinone Derivatives Through Copper Catalyzed C–H Amidation Reactions
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    126. Ichake, S. S.; Rajawinslin, R. R.; Kavala, V.; Villuri, B. K.; Yang, H.-T.; Kuo, C.-W.; Yao, C.-F.* Asian J. Org. Chem. 2016, 5(3), 343-352. (3) (Organic Chemistry: 16/59, 2015 IF: 3.275; 5 year impact factor: 3.296) Online ISSN: 2193-5815 (Times Cited: 0)
    NBS Mediated Thiocyanation of Cyclohexene Fused Isoxazoline N-Oxides
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    125. Chang, K. H.; Chiu, Y. J.; Chen, S. L.; Huang, C. H.; Lin, C. H.; Lin, T. H.; Lee, C. M.; Ramesh, C.; Wu, C. H., Huang, C. C.; Fung, H. C.; Chen, Y. C.; Lin, J. Y.; Yao, C. F.; Huang, H. J.; Lee-Chen, G. J.*; Lee, M. C.*; Hsieh-Li, H. M.* Neuropharmacology 2016101, 309-319. (2) (Field of Pharmacology & Pharmacy: 19/253, 2015 IF:4.936; 5 year impact factor: 4.709) Online ISSN 0028-3908 (Times Cited: 1)
    The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    124. Liu,C.-Y.; Wu, P.-T.; Wang, J.-P.; Fan, P.-W.; Hsieh, C.-H.; Su, C.; Chiu, C.-C.; Yao, C.-F.; Fang, K.* Apoptosis 201520(11), 1471-1482. (12) (Field of Biochemistry & Molecular Biology: 93/289 or Cell Biology: 80/180, 2014 IF:3.592; 5 year impact factor: 3.617) ISSN: 1360-8185 (Print) 1573-675X (Online) (Times Cited: 3)
    An indolylquinoline derivative promotes apoptosis in human lung cancer cells by impairing mitochondrial functions
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    123. Chen, W.-C.: Lin, C.-C.; Kavala, V.; Kuo, C.-W.; Huang, C.-Y.; Yao, C.-F.* Molecules 201520(12), 22419-22519. (12) (Organic Chemistry: 24/59, 2015 IF: 2.465; 5 year impact factor: 2.749) Online ISSN 1420-3049 (Times Cited: 0)
    Syntheses of 4-Indolylquinoline Derivatives via Reductive Cyclization of Indolylnitrochalcone Derivatives by Fe/HCl
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    122. Rajawinslin, R. R.; Gawande, S. D.; Kavala, V.; Huang, Y.-H. ; Kuo, C.-W.; Kuo, T.-S.; Chen, M.-L.; He, C.-H.; Yao, C.-F.* RSC Adv., 20155 (64), 52141-52153. (7) (Chemistry, Multidisciplinary: 48/163, 2015 IF: 3.289; 5 year impact factor: 3.485) Online ISSN: 2046-2069 (Times Cited: 2)
    Iron/acetic acid mediated synthesis of 6,7-dihydrodibenzo [b,j] [1,7] phenanthroline derivatives via intramolecular reductive cylization
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    121. Chen, W.-C.: Kavala, V.; Shih, Y.-H.; Wang, Y.-H.; Kuo, C.-W.; Yang, T.-H.; Huang, C.-Y.; Chiu, H,-H.; Yao, C.-F.* Molecules 201520(6), 10910-10927. (6) (Organic Chemistry: 24/59, 2015 IF: 2.465; 5 year impact factor: 2.749) Online ISSN 1420-3049 (Times Cited: 1)
    Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    120. Gawande, S. D.; Zanwar, M. R.; Kavala, V.; Kuo, C.-W.; Yao, C.-F.* Adv. Synth. Catal. 2015, 375(1), 168-175. (1) (Applied Chemistry: 1/71 or Organic Chemistry: 5/59, 2015 IF: 6.453; 5 year impact factor: 5.852) Online ISSN: 1615-4169 (Times Cited: 2)
    One Pot Synthesis of 2-Arylquinaloine and Tetracyclic-Isoindolo[1,2-a]quinazoline Derivatives via Cyanation Followed by the Rearrangement of o-Substituted 2-Halo-N-Arylbenzamides
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    119. Meesala, Y.; Kavala, V.; Chang , H.-C.; Kuo, T.-S.; Yao, C.-F.*; Lee, W.-Z.* Dalton Trans. 2015, 44(3), 1120-1129. (1) (Inorganic & Nuclear Chemistry: 6/45, 2015 IF: 4.177; 5 year impact factor: 4.003) Online ISSN: 1477-9226 (Times Cited: 6)
    Synthesis, structures and electrochemical and photophysical properties of anilido-benzoxazole boron difluoride (ABB) complexes
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    118. Zanwar, M. R.; Gawande, S. D.; Kavala, V.; Kuo, C.-W.; Yao, C.-F.* Adv. Synth. Catal. 2014, 356(18), 3849-3860. (12) (Applied Chemistry: 2/71 or Organic Chemistry: 5/58, 2013 IF: 5.542) Online ISSN: 1615-4169 (Times Cited: 3)
    Iron(III)chloride Catalyzed Synthesis of Highly Substituted Indolyl-Tetrahydroquinoline Derivatives by Using Electron Deficient Dienophiles and Its Application to the Synthesis of Indolo-Benzonaphthyridine Derivatives
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    117. Lin, C.-H.; Wu, Y.-R.; Kung, P.-J.; Chen, W.-L.; Lee, L.-C.; Lin, T.-H.; Chao, C.-Y.; Chen, C.-M.; Chang, K.-H.; Janreddy, D.; Lee-Chen, G.-J.*; Yao, C.-F.* ACS Chem. Neurosci.20145(10), 1063-1074. (10)  ISSN: 1948-7193 (Times Cited: 2) (Neuroscience: 65/251, 2013 IF: 4.210) published online September 8, 2014
    The Potential of Indole and a Synthetic Derivative for PolyQ Aggregation Reduction by Enhancement of the Chaperone and Autophagy Systems
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    116. Kung, P.-J.; Tao, Y.-C.; Hsu, H.-C.; Chen, W.-L.; Lin, T.-H.; Janreddy, D.; Yao, C.-F.; Cahng, K.-H.; Lin, J.-Y.; Su, M.-T.; Wu, C.-H.; Lee-Chen, G.-J.*; Hsieh-Li, H.-M.* Drug Design, Development and Therapy 2014, 8, 1929-1939. (10) (Pharmacology & Pharmacy 76/254, 2014 IF: 3.03) Online ISSN: 1177-8881 (Times Cited: 2)
    Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    115. Kotipalli, T.; Janreddy, D.; Kavala, V.; Kuo, C.-W.; Kuo, T.-S.; Chen, M.-L.; He, C.-H.; Yao, C.-F.* RSC Adv.20144(88), 47833-47840. (10) (Chemistry, Multidisciplinary: 35/148, 2013 IF:  3.840; 5 year impact factor: 3.907) Online ISSN: 2046-2069 (Times Cited: 0)
    BF3•OEt2-mediated one pot synthesis of 10-indolyldibenzo[b,f]azepine derivatives via tandem ring expansion and C-C bond formation
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    114. Janreddy, D.; Kavala, V.; Kotipalli, T.; Kuo, C.-W.; Kuo, T.-S.; Chen, M.-L.; He, C.-H.; Yao, C.-F.* Adv. Synth. Catal. 2014, 356(14-15), 3083-3091. (10) (Applied Chemistry: 2/71 or Organic Chemistry: 5/58, 2013 IF: 5.542) Online ISSN: 1615-4169  (Times Cited: 0)
    Palladium(II)Chloride Catalyzed Aerobic Oxidative Intermolecular [4+2] Cycloaddition Reaction of 2-Alkynyl Benzaldehydes and Electron-Deficient Terminal Alkenes: An Efficient Synthesis of Naphthyl ketones
    計畫編號: NSC-100-2113-M-003-008-MY3
    Kavala, V.; Wang, C.-C.; Barange, D. K.; Kuo, C.-W.; Lei, P.-M.; Yao, C.-F.* J. Org. Chem. 201277(11), 5022-5029. (6) (Organic Chemistry: 10/57, 2012 IF: 4.564) Online ISSN: 1520-6904 (Times Cited: 42)
    Synthesis of Isocoumarin Derivatives via the Copper-Catalyzed Tandem Sequential Cyclization of 2- Halo-N-phenyl Benzamides and Acyclic 1,3-Diketones
    計畫編號: NSC-100-2113-M-003-008-MY3