Faculty

Name	Ling-Hsien Tu
Email	litu@ntnu.edu.tw
Office Tel No.	02-7749-6157
Title	Professor

Year	Paper Title
2024	Unraveling the Underlying Mechanisms of Reduced Amyloidogenic Properties in Human Calcitonin via Double Mutations, Protein Science, Apr. 2024
2024	TPE conjugated islet amyloid polypeptide probe for detection of peptide oligomers, Biophysical Chemistry, Jan. 2024
2023	Beta amyloid oligomers with higher cytotoxicity have higher sidechain dynamics, Chemistry – A European Journal, Oct. 2023
2023	Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity, Chemical Communications, vol. 59, Aug. 2023
2023	Synthesis of Fe3O4-Chlorophyllin Nanoparticles for Preventing Amyloid Formation by Human Calcitonin, ACS Applied Nano Materials, vol. 6, Jul. 2023
2023	Investigating the inhibitory property of DM hCT on hCT fibrillization via its relevant peptide fragments, Protein Science, vol. 32, Jun. 2023
2023	An environmentally sensitive molecular rotor as a NIR fluorescent probe for the detection of islet amyloid polypeptide, Talanta, vol. 254, Mar. 2023
2022	Aβ42 oligomers can seed the fibrillization of Aβ40 peptides, Journal of the Chinese Chemical Society, Aug. 2022
2022	Dihydrocaffeic acid decorated iron oxide nanomaterials effectively inhibit human calcitonin aggregation, ACS Omega, vol. 7, Aug. 2022
2022	Site specific NMR characterization of abeta-40 oligomers cross seeded by abeta-42 oligomers, Chemical Science, vol. 13, Jun. 2022
2022	Tyrosine 12 of human calcitonin modulates its amyloid formation, membrane binding, and bioactivity, Biochimie, vol. 197, Jun. 2022
2022	The Role of Aldehyde-Functionalized Crosslinkers on the Property of Chitosan Hydrogels, Macromolecular Bioscience, Feb. 2022
2021	Dopamine-Conjugated Carbon Dots Inhibit Human Calcitonin Fibrillation, nanomaterials, vol. 11, Aug. 2021
2021	Exploring the impact of glyoxal glycation on β-amyloid peptide (Aβ) aggregation in Alzheimer's disease, J. Phys. Chem. B, May. 2021
2020	TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease, Nature Communications, vol. 11, Dec. 2020
2020	Role of Lysine Residue of Islet Amyloid Polypeptide in Fibril Formation, Membrane Binding, and Inhibitor Binding, Biochimie, vol. 177, Aug. 2020
2020	A Fluorogenic Molecule for Probing Islet Amyloid Using Flavonoid as a Scaffold Design, Biochemistry, vol. 59, Apr. 2020
2019	Inhibiting Human Calcitonin Fibril Formation with Its Most Relevant Aggregation-Resistant Analog, J. Phys. Chem. B, vol. 123, Nov. 2019
2019	Protein Glycation by Glyoxal Promotes Amyloid Formation by Islet Amyloid Polypeptide, Biophysical Journal, vol. 116, Jun. 2019
2018	Rationally designed divalent caffeic amides inhibit amyloid-β fibrillization, induce fibril dissociation, and ameliorate cytotoxicity, European Journal of Medicinal Chemistry, vol. 158, Oct. 2018
2017	A Free Energy Barrier Caused by the Refolding of an Oligomeric Intermediate Controls the Lag Time of Amyloid Formation by hIAPP, Journal of the American Chemical Society, vol. 139, Nov. 2017
2017	Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers, Chemical Science, vol. 8, May. 2017
2016	Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics, eLIFE, vol. N/A, May. 2016
2016	Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology, Journal of Diabetes Research, vol. 2016, Jan. 2016
2015	Matrix metalloproteinase-9 protects islets from amyloidinduced toxicity, Journal of Biological Chemistry, vol. 290, Dec. 2015
2015	Insights into the consequences of co-polymerisation in the early stages of IAPP and Aβ peptide assembly from mass spectrometry, Analyst, vol. 140, Oct. 2015
2015	Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry–mass spectrometry, Nature Chemistry, vol. 7, Jan. 2015
2015	Mutational Analysis of the Ability of Resveratrol To Inhibit Amyloid Formation by Islet Amyloid Polypeptide: Critical Evaluation of the Importance of Aromatic−Inhibitor and Histidine−Inhibitor Interactions, Biochemistry, vol. 54, Jan. 2015
2014	Aspirin, Diabetes, and Amyloid: Re-examination of the Inhibition of Amyloid Formation by Aspirin and Ketoprofen, ACS Chemical Biology, vol. 9, May. 2014
2014	Mutational Analysis of Preamyloid Intermediates: The Role of His-Tyr Interactions in Islet Amyloid Formation, Biophysical Journal, vol. 106, Apr. 2014
2013	Islet amyloid polypeptide toxicity and membrane interactions, Proceedings of the National Academy of Sciences of the United States of America, vol. 110, Nov. 2013
2013	Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity, FEBS Letters, vol. 578, Apr. 2013
2013	Role of Aromatic Interactions in Amyloid Formation by Islet Amyloid Polypeptide, Biochemistry, vol. 52, Jan. 2013
2012	Sensitivity of Amyloid Formation by Human Islet Amyloid Polypeptide to Mutations at Residue 20, Journal of Molecular Biology, vol. 421, Aug. 2012
2006	CeCl3·7H2O-NaI catalyzed intramolecular addition reactions of 7-hydroxy-1,3-dienes: a facile approach to hexahydrobenzofurans and tetrahydrofurans, Tetrahedron, vol. 62, Jun. 2006
2005	Palladium-Catalyzed Reaction of Aryl Bromides with 7-Hydroxy-1,3-Dienes, Organometallics, vol. 24, Oct. 2005
2004	Rhodium(I)-Catalyzed Intramolecular Cyclohexadienyl Pauson-Khand Reaction: Facile Approach to Tricarbocycles, Organometallics, vol. 23, Jan. 2004

Year	Paper Title
2019	Minimum Acquisition of Double Mutation in Human Calcitonin Enhances its Resistance to Fibrillization and its Use as Therapeutic Polypeptides, 26th American peptide symposium, Jun. 22-27, 2019, Monterey, USA

Year	Project Title	Participator	Job Title	Period	Unit
2022	以第二型糖尿病中有毒蛋白質寡聚體為目標，發展其偵測方式及策略計畫以調控其生成(2/3)			2021.08 ~ 2022.07	國科會
2021	以第二型糖尿病中有毒蛋白質寡聚體為目標，發展其偵測方式及策略計畫以調控其生成(1/3)		主持人	2020.08 ~ 2021.07	科技部(原國科會)
2019	光敏性抗菌奈米纖維不織布於傷口敷料上之應用	國立臺灣師範大學	協同/共同主持人	2019.03 ~ 2019.12	其他
2020	探討與氧化壓力相關的異常鍵結修飾對阿茲海默病症β-類澱粉蛋白質聚集的影響		主持人	2018.08 ~ 2020.07	科技部(原國科會)
2018	研究醣化過程造成類澱粉蛋白產生的機制		主持人	2016.12 ~ 2018.07	科技部(原國科會)

Country	School Name	Department	Degree	Duration
United States	Stony Brook University	Department of Chemistry	doctor	2008.08 ~ 2014.08
Taiwan	National Taiwan Normal University	Department of Chemistry	master	2003.09 ~ 2005.07
Taiwan	National Taiwan Normal University	Department of Chemistry	Bachelor	1999.09 ~ 2003.06

Organization Title	Department	Job Title	Duration
			2021.02 ~ Up to today
National Taiwan Normal Univeristy	Department of Chemistry	Assistant Professor	2016.08 ~ 2021.01
Acdemia Sinica	Genomic Research Center	Distinguished Postdoctoral Scholars	2014.09 ~ 2016.07

Department of Chemistry, NTNU

Department of Chemistry, NTNU